Unfortunately this can't be done. The code would have to be in some kind of web project, and then you would have to use IE as your main development browser. Personally I started out years ago using the Visual Studio/IE debugging but find it prohibitively slow now.
Anyway this point is moot anyway because you don't want to debug a web app :)
As far as an alternative solution I can thoroughly recommend WebStorm by JetBrains, they really do a bang up job with the IDEs... and this is coming from a die hard Visual Studio guy! While I can't profess to being an expert with it the times I have used it I found the configuration reasonably easy, and it fully supports nodejs and all that stuff.
Hope this helps even though it's not the answer you were hoping for