Below is some code that will click on the desktop at (900, 50) using pywinauto.
Note that using ClickInput() rather than Click() is important.
import pywinauto.application
app = pywinauto.application.Application()
comapp = app.connect_(path = "explorer")
for i in comapp.windows_():
if "Progman" == i.FriendlyClassName():
i.ClickInput(coords=(900, 50))